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A convenient synthesis of 2,6-Dichloromonicotinic acid.

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dc.contributor.author Buchanan, Chase;
dc.contributor.author Fitch Richard
dc.date.accessioned 2012-05-21T18:29:50Z
dc.date.accessioned 2015-10-05T14:44:07Z
dc.date.available 2012-05-21T18:29:50Z
dc.date.available 2015-10-05T14:44:07Z
dc.date.issued 2012-05-21T18:29:50Z
dc.identifier.uri http://hdl.handle.net/10484/4027
dc.description.abstract In our synthetic efforts toward the alkaloid phantasmidine, we required a convenient source of the title compound. Herein, we describe a short synthesis of 2,6-dichlorohomonicotinic acid by direct allylation of 2,6-dichloropyridine with LDA/allyl chloride, followed by permanganate oxidation of the side chain [figure1]. Yields for the allylation are high, while permanganate oxidation required more adjustment. Successful conditions require the modest acidification of the mixture with acetic acid and cleanup by acid base workup. No chromatography is needed.
dc.language.iso en_US
dc.subject synthesis of 2,6-dichlorohomonicotinic acid
dc.title A convenient synthesis of 2,6-Dichloromonicotinic acid.
dc.date.published 2012
dc.description.department Department of Chemistry and Physics
dc.description.facultysponsor Fitch Richard
dc.description.itemidcsrc ILL-ETD-006


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