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dc.contributor.authorRebecca Norcross
dc.contributor.authorJessica Stanfield
dc.contributor.authorRichard W. Fitch
dc.date.accessioned2012-05-21T19:46:34Z
dc.date.accessioned2015-10-05T14:44:08Z
dc.date.available2012-05-21T19:46:34Z
dc.date.available2015-10-05T14:44:08Z
dc.date.issued2012-05-21T19:46:34Z
dc.identifier.urihttp://hdl.handle.net/10484/4032
dc.description.abstractWhile preparing novel cysteine derivatives as oxidation catalysts, we needed S-tert-butylcysteine. We also examined acid-promoted tert-butylation of thiols using tert-butanol as reagent and solvent. While cysteine and aminoethanethiol work well using tBuOH in 4M HCl, other thiols fail in the aqueous environment and aerobic conditions. We examined a variety of aliphatic and aromatic thiols in tBuOH with H2SO4 catalysis and found that argon sparging and the use of 1 eq of acid led to good yields in a parallel format.
dc.language.isoen_US
dc.subjectnovel cysteine
dc.titleConvenient Parallel Synthesis of Alkyl- and Aryl-S-tert-Butyl Thiothers
dc.date.published2012
dc.description.facultysponsorRichard W. Fitch
dc.description.itemidcsrcILL-ETD-011
refterms.dateFOA2021-06-02T11:47:59Z


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