• Manipulation of Angiogenesis by Cyclosporine-A and Extracellular Matrix Molecules

      Pandey, Raghav (2012-10-19)
      Angiogenesis is the formation of new capillaries from pre-existing capillaries. Angiogenesis plays an important role in the blood vessel formation required during embryonic development, tissue injury, wound healing, and menstruation. It also plays a major role in tumor progression. We propose a mechanism that links the developmental pathways to a therapeutic pathway. Moreover, we show anti-angiogenic nature of an FDA approved immunosuppressant. Extra cellular matrix (ECM) has an important role in maintaining the shape and structure of organisms and in signaling mechanisms. Two major components of ECM are lumican and Magp2. Investigating their role might help us further link angiogenesis to tumor progression in cancer. We show the pro-angiogenic nature of Magp2 in an in-vivo model. Although this project is in early stages, it would provide a good foundation for future study. The aim of this thesis was to check the effect of blocking angiogenesis on tumor growth through different ECM proteins (Lumican and Magp2) and therapeutics (cyclosporine-A). Studying the progression of tumor links the chapters together.